Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31179099 | 0.80 | ABL1 (0.35) | CYP4F2CYP4A11ABL1LMNAESR1 | |
| SCHEMBL29474165 | 0.79 | — | — | |
| SCHEMBL31550224 | 0.77 | ALDH1A1 (0.33) | CYP4F2CYP4A11ABL1LMNAESR1 | |
| SCHEMBL31600258 | 0.75 | ABL1 (0.35) | CYP4F2CYP4A11ABL1LMNAESR1 | |
| SCHEMBL24274219 | 0.74 | FLT3 (0.31) | — | |
| SCHEMBL31127814 | 0.74 | RET (0.32) | CYP2C19 | |
| SCHEMBL457479 | 0.72 | CYP2C19 (0.33) | ABL1LMNACYP2C19 | |
| SCHEMBL15263438 | 0.71 | CYP4F2 (0.34) | CYP4F2CYP4A11ABL1LMNAESR1 | |
| SCHEMBL31550223 | 0.71 | ATR (0.35) | CYP4F2CYP4A11ABL1 | |
| SCHEMBL31600834 | 0.70 | ABL1 (0.35) | CYP4F2CYP4A11ABL1LMNAESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4217358-A1 | INDAZOLES AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) INHIBITORS AND METHODS OF USING SAME | 1st Biotherapeutics, Inc. (KR) | 2023-08-02 | — | — | EP | disclosed |
| WO-2022064459-A1 | INDAZOLES AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) INHIBITORS AND METHODS OF USING SAME | 1ST Biotherapeutics, Inc. (KR) | 2022-03-31 | — | — | WO | disclosed |
| WO-2022064458-A1 | INDAZOLES AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) INHIBITORS AND METHODS OF USING SAME | 1ST Biotherapeutics, Inc. (KR) | 2022-03-31 | — | — | WO | disclosed |