⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28811081 | 0.78 | MAP4K1 (0.39) | — | |
| SCHEMBL29474183 | 0.78 | MAP4K1 (0.39) | — | |
| SCHEMBL25463789 | 0.75 | CHUK (0.34) | — | |
| SCHEMBL29474188 | 0.74 | — | — | |
| SCHEMBL24274335 | 0.74 | — | — | |
| SCHEMBL29474177 | 0.73 | IDO1 (0.34) | — | |
| SCHEMBL24294312 | 0.72 | MAP4K1 (0.32) | — | |
| SCHEMBL24558302 | 0.70 | TSHR (0.36) | — | |
| SCHEMBL31107239 | 0.70 | TSHR (0.36) | — | |
| SCHEMBL29474172 | 0.68 | GRIN2D (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4217358-A1 | INDAZOLES AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) INHIBITORS AND METHODS OF USING SAME | 1st Biotherapeutics, Inc. (KR) | 2023-08-02 | — | — | EP | disclosed |
| WO-2022064459-A1 | INDAZOLES AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) INHIBITORS AND METHODS OF USING SAME | 1ST Biotherapeutics, Inc. (KR) | 2022-03-31 | — | — | WO | disclosed |
| WO-2022064458-A1 | INDAZOLES AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) INHIBITORS AND METHODS OF USING SAME | 1ST Biotherapeutics, Inc. (KR) | 2022-03-31 | — | — | WO | disclosed |