SCHEMBL29476578

SCHEMBL29476578

CC(C)[C@H](NC(=O)[C@@H](N)CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CS)C(=O)O

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ IL23R Q5VWK5 19/20 0.59
▸ KISS1R Q969F8 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29476380 1.00 IL23R (0.59) IL23RKISS1R
SCHEMBL29476520 0.93 IL23R (0.54) IL23RKISS1R
SCHEMBL29476435 0.93 IL23R (0.54) IL23RKISS1R
SCHEMBL29476401 0.93 IL23R (0.56) IL23RKISS1R
SCHEMBL29476449 0.93 IL23R (0.56) IL23RKISS1R
SCHEMBL29476609 0.91 IL23R (0.52) IL23RKISS1R
SCHEMBL29476531 0.91 IL23R (0.52) IL23RKISS1R
SCHEMBL29476439 0.90 KISS1R (0.55) IL23RKISS1R
SCHEMBL29476441 0.90 KISS1R (0.55) IL23RKISS1R
SCHEMBL30198819 0.90 ACE (0.54) IL23RKISS1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118271400-A Peptide composition 节奏制药公司 2024-07-02 — — CN claimed
CN-118240012-A Peptide composition 节奏制药公司 2024-06-25 — — CN claimed
CN-105492456-B Peptide composition 节奏制药公司 2024-11-01 — — CN disclosed
CN-118271400-A Peptide composition 节奏制药公司 2024-07-02 — — CN disclosed
CN-118240012-A Peptide composition 节奏制药公司 2024-06-25 — — CN disclosed
EP-4216979-A1 METHODS OF TREATING MELANOCORTIN-4 RECEPTOR PATHWAY-ASSOCIATED DISORDERS Rhythm Pharmaceuticals, Inc. (US) 2023-08-02 — — EP disclosed
CN-116507353-A Methods of treating melanocortin-4 receptor pathway-related disorders 节奏制药公司 2023-07-28 — — CN disclosed
CN-115957297-A Pharmaceutical composition 节奏制药公司 2023-04-14 — — CN disclosed
CN-115957296-A Pharmaceutical composition 节奏制药公司 2023-04-14 — — CN disclosed
WO-2022067086-A1 METHODS OF TREATING MELANOCORTIN-4 RECEPTOR PATHWAY-ASSOCIATED DISORDERS RHYTHM PHARMACEUTICALS, INC. (US) 2022-03-31 — — WO disclosed
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