SCHEMBL2947712

SCHEMBL2947712

C#Cc1nnc(N2C[C@@H]3C[C@H]2CN3C)s1.c1cc2cc-2c1

nearest known ligand 0.44

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 14/20 0.44
KCNH2 Q12809 12/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2947707 0.76 CHRNA7 (0.45) CHRNA7KCNH2
SCHEMBL2943783 0.74 CHRNA7 (0.47) CHRNA7KCNH2
SCHEMBL2949253 0.71 CHRNA7 (0.50) CHRNA7KCNH2
Benzene SCHEMBL2929682 0.66 CHRNA7 (0.44) CHRNA7KCNH2
SCHEMBL4839260 0.64 CHRNA7 (0.47) CHRNA7KCNH2
SCHEMBL4109514 0.61 CHRNA7 (1.00) CHRNA7KCNH2
SCHEMBL6627648 0.61 CHRNA7 (1.00) CHRNA7KCNH2
SCHEMBL4109510 0.61 CHRNA7 (1.00) CHRNA7KCNH2
SCHEMBL4109513 0.61 CHRNA7 (1.00) CHRNA7KCNH2
SCHEMBL9141111 0.60 CHRNA7 (0.44) CHRNA7KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7750011-B2 Diazabicyclic aryl derivatives and their medical use NEUROSEARCH A/S (DK) 2010-07-06 US claimed
US-20080161314-A1 Novel Diazabicyclic Aryl Derivatives and Their Medical Use NEUROSEARCH A/S (DK) 2008-07-03 US claimed
EP-1866314-A1 NOVEL DIAZABICYCLIC ARYL DERIVATIVES AND THEIR MEDICAL USE NeuroSearch A/S (DK) 2007-12-19 EP claimed
WO-2006087305-A1 NOVEL DIAZABICYCLIC ARYL DERIVATIVES AND THEIR MEDICAL USE NEUROSEARCH A/S (DK) 2006-08-24 WO claimed
US-7750011-B2 Diazabicyclic aryl derivatives and their medical use NEUROSEARCH A/S (DK) 2010-07-06 US disclosed
US-20080161314-A1 Novel Diazabicyclic Aryl Derivatives and Their Medical Use NEUROSEARCH A/S (DK) 2008-07-03 US disclosed
EP-1866314-A1 NOVEL DIAZABICYCLIC ARYL DERIVATIVES AND THEIR MEDICAL USE NeuroSearch A/S (DK) 2007-12-19 EP disclosed
WO-2006087305-A1 NOVEL DIAZABICYCLIC ARYL DERIVATIVES AND THEIR MEDICAL USE NEUROSEARCH A/S (DK) 2006-08-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080161314-A1 Novel Diazabicyclic Aryl Derivatives and Their Medical Use CHRNA6, CHRNA10, CHRNA2 CHRNA7 7/4885KCNH2 719/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.