SCHEMBL29478316

SCHEMBL29478316

C=C[C@H]1O[C@@H](n2cc(Br)c3c(N)ncnc32)[C@H](F)[C@@H]1O

nearest known ligand 0.63

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ ADK P55263 6/20 0.63
▸ METTL3 Q86U44 14/20 0.59
▸ PRMT5 O14744 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24293504 0.91 ADK (0.63) ADKMETTL3
SCHEMBL24293915 0.91 ADK (0.75) ADKMETTL3
SCHEMBL29478307 0.82 ADK (0.56) ADKMETTL3
SCHEMBL29365390 0.81 ADK (0.67) ADKMETTL3PRMT5
SCHEMBL24293493 0.81 ADK (0.67) ADKMETTL3PRMT5
SCHEMBL29478317 0.80 ADK (0.47) ADKMETTL3PRMT5
SCHEMBL24293515 0.79 ADK (0.57) ADKMETTL3PRMT5
SCHEMBL24293687 0.79 ADK (0.69) ADKMETTL3
SCHEMBL31725326 0.77 ADK (0.71) ADKMETTL3PRMT5
SCHEMBL24293844 0.77 ADK (0.52) ADKMETTL3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022074391-A1 COMPOUNDS INHIBITORS OF METTL3 STORM THERAPEUTICS LIMITED (GB) 2022-04-14 — — WO disclosed
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