Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24373240 | 1.00 | MEN1 (0.32) | MEN1KMT2AHDAC1HDAC6EPAS1 | |
| SCHEMBL30662731 | 0.85 | MEN1 (0.34) | MEN1KMT2AEPAS1 | |
| SCHEMBL22331229 | 0.85 | MEN1 (0.34) | MEN1KMT2AEPAS1 | |
| SCHEMBL20872550 | 0.79 | CHRM2 (0.34) | MEN1KMT2A | |
| SCHEMBL29628557 | 0.79 | CHRM2 (0.34) | MEN1KMT2A | |
| SCHEMBL3093413 | 0.79 | MEN1 (0.33) | MEN1KMT2A | |
| SCHEMBL25015121 | 0.76 | MEN1 (0.32) | MEN1KMT2A | |
| SCHEMBL3097748 | 0.76 | CHRM2 (0.32) | MEN1KMT2A | |
| SCHEMBL13069751 | 0.75 | DAO (0.33) | MEN1KMT2A | |
| SCHEMBL10324344 | 0.73 | MEN1 (0.33) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232444-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022083569-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2022-04-28 | — | — | WO | disclosed |