SCHEMBL29478948

SCHEMBL29478948

CC1(C)OB(c2c(Cl)ccc3c2cnn3C2CCCCO2)OC1(C)C

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
RXRA P19793 1/20 0.38
RXRB P28702 1/20 0.38
RXRG P48443 1/20 0.38
DGAT2 Q96PD7 1/20 0.36
CYP4F2 P78329 3/20 0.34
CYP4A11 Q02928 3/20 0.34
ALDH1A1 P00352 1/20 0.34
LMNA P02545 1/20 0.34
POLB P06746 1/20 0.34
YTHDC1 Q96MU7 1/20 0.31
CYP1A2 P05177 1/20 0.30
HPGD P15428 1/20 0.30
RET P07949 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21393943 1.00 RXRA (0.38) RXRARXRBRXRGDGAT2CYP4F2
SCHEMBL29384146 0.88 CYP4F2 (0.39) RXRARXRBRXRGDGAT2CYP4F2
SCHEMBL16647245 0.88 CYP4F2 (0.39) RXRARXRBRXRGDGAT2CYP4F2
SCHEMBL23546535 0.87 RXRA (0.36) RXRARXRBRXRGDGAT2CYP4F2
SCHEMBL25795327 0.87 RXRA (0.40) RXRARXRBRXRGDGAT2CYP4F2
SCHEMBL30641330 0.86 RXRA (0.38) RXRARXRBRXRGDGAT2CYP4F2
SCHEMBL29418904 0.86 CYP4F2 (0.36) RXRARXRBRXRGDGAT2CYP4F2
SCHEMBL21243898 0.86 CYP4F2 (0.36) RXRARXRBRXRGDGAT2CYP4F2
SCHEMBL26674786 0.86 RXRA (0.38) RXRARXRBRXRGDGAT2CYP4F2
SCHEMBL24373802 0.85 RXRA (0.37) RXRARXRBRXRGDGAT2CYP4F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4551577-A1 FUSED RING KRAS INHIBITORS FOR TREATING DISEASE Blossomhill Therapeutics, Inc. (US) 2025-05-14 EP disclosed
EP-4526293-A1 HETEROARENES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME Repare Therapeutics Inc. (CA) 2025-03-26 EP disclosed
EP-4359081-A1 PYRAZOLYL DERIVATIVES AS INHIBITORS OF THE KRAS MUTANT PROTEIN Novartis AG (CH) 2024-05-01 EP disclosed
WO-2024015262-A1 FUSED RING KRAS INHIBITORS FOR TREATING DISEASE BLOSSOMHILL THERAPEUTICS, INC. (US) 2024-01-18 WO disclosed
WO-2023220831-A1 HETEROARENES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME REPARE THERAPEUTICS INC. (CA) 2023-11-23 WO disclosed
EP-4232444-A1 HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE Amgen Inc. (US) 2023-08-30 EP disclosed
WO-2022269508-A1 PYRAZOLYL DERIVATIVES AS INHIBITORS OF THE KRAS MUTANT PROTEIN NOVARTIS AG (CH) 2022-12-29 WO disclosed
EP-4076662-A1 PYRAZOLYL DERIVATIVES USEFUL AS ANTI-CANCER AGENTS Novartis AG (CH) 2022-10-26 EP disclosed
CN-114929342-A Pyrazolyl derivatives as anticancer agents 诺华股份有限公司 2022-08-19 CN disclosed
WO-2022083569-A1 HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE AMGEN INC. (US) 2022-04-28 WO disclosed