Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 15/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 11/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.34 |
| ▸ | F7 | P08709 | 1/20 | 0.34 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.34 |
| ▸ | CTRL | P40313 | 1/20 | 0.34 |
| ▸ | CTRB2 | Q6GPI1 | 1/20 | 0.34 |
| ▸ | CTRC | Q99895 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16971368 | 1.00 | F11 (0.43) | F11KLKB1NOTUMKCNMA1CYP3A4 | |
| SCHEMBL16971811 | 0.93 | NOTUM (0.41) | F11KLKB1NOTUMKCNMA1KCNH2 | |
| SCHEMBL16971836 | 0.89 | NOTUM (0.38) | F11KLKB1NOTUMKCNMA1KCNH2 | |
| SCHEMBL16971865 | 0.89 | NOTUM (0.39) | F11KLKB1NOTUMKCNMA1KCNH2 | |
| SCHEMBL16971474 | 0.88 | F11 (0.38) | F11KLKB1NOTUMKCNMA1KCNH2 | |
| SCHEMBL30271707 | 0.88 | F11 (0.38) | F11KLKB1NOTUMKCNMA1KCNH2 | |
| SCHEMBL16971576 | 0.87 | NOTUM (0.41) | F11KLKB1NOTUMKCNMA1CYP3A4 | |
| SCHEMBL16971848 | 0.87 | NOTUM (0.47) | F11KLKB1NOTUMKCNMA1KCNH2 | |
| SCHEMBL16971389 | 0.87 | NOTUM (0.60) | NOTUMKCNMA1KCNH2 | |
| SCHEMBL16971418 | 0.86 | F11 (0.40) | F11KLKB1NOTUMCYP3A4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120118085-A | Preparation method of Milvexian | 中国药科大学 | 2025-06-10 | — | — | CN | claimed |
| CN-120118085-A | Preparation method of Milvexian | 中国药科大学 | 2025-06-10 | — | — | CN | disclosed |
| CN-114805365-B | Factor XIA new macrocycles carrying non-aromatic P2' groups | 百时美施贵宝公司 | 2024-07-23 | — | — | CN | disclosed |
| CN-115515938-B | Salts of FXIa inhibitor compounds, preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2024-05-10 | — | — | CN | disclosed |
| CN-117120418-A | Process for the preparation of compound (I) | 百时美施贵宝公司 | 2023-11-24 | — | — | CN | disclosed |
| CN-116987080-A | Macrocyclic compounds with heterocyclic P2' groups as factor XIA inhibitors | 百时美施贵宝公司 | 2023-11-03 | — | — | CN | disclosed |
| EP-4225757-A1 | A PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}-1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B] [1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE | Bristol-Myers Squibb Company (US) | 2023-08-16 | — | — | EP | disclosed |
| CN-116120240-A | FXIa inhibitor compound, preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2023-05-16 | — | — | CN | disclosed |
| CN-115427043-B | Medical application of FXIa inhibitor compound or salt thereof | 深圳信立泰药业股份有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-114206854-B | FXIa inhibitor and preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2023-02-24 | — | — | CN | disclosed |
| CN-115515938-A | Salt of FXIa inhibitor compound and preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2022-12-23 | — | — | CN | disclosed |
| CN-115427043-A | Medical application of FXIa inhibitor compound or salt thereof | 深圳信立泰药业股份有限公司 | 2022-12-02 | — | — | CN | disclosed |
| CN-114957255-A | Pyrimidinones as factor XIA inhibitors | 百时美施贵宝公司 | 2022-08-30 | — | — | CN | disclosed |
| CN-114874222-A | Carrying non-aromatic P2 , Novel macrocyclic form of factor XIA | 百时美施贵宝公司 | 2022-08-09 | — | — | CN | disclosed |
| CN-114805365-A | Carrying non-aromatic P2 , Novel macrocyclic form of factor XIA | 百时美施贵宝公司 | 2022-07-29 | — | — | CN | disclosed |
| CN-110734435-B | Pyrimidinones as factor XIA inhibitors | 百时美施贵宝公司 | 2022-06-07 | — | — | CN | disclosed |
| WO-2022083706-A1 | SALTS OF FXIA INHIBITOR COMPOUNDS, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | 深圳信立泰药业股份有限公司 | 2022-04-28 | — | — | WO | disclosed |
| WO-2022083707-A1 | PHARMACEUTICAL USE OF FXIA INHIBITOR COMPOUND OR SALT THEREOF | 深圳信立泰药业股份有限公司 | 2022-04-28 | — | — | WO | disclosed |
| WO-2022081473-A1 | A PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}-1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B] [1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-04-21 | — | — | WO | disclosed |
| CN-114206854-A | FXIa inhibitor and preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2022-03-18 | — | — | CN | disclosed |