Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.60 |
| ▸ | MGAM | O43451 | 1/20 | 0.58 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2944179 | 0.89 | CYP19A1 (0.60) | CYP19A1MGAMRAD51MEN1KMT2A | |
| SCHEMBL2944188 | 0.84 | MEN1 (0.69) | CYP19A1MGAMRAD51MEN1KMT2A | |
| SCHEMBL2949600 | 0.82 | NR3C1 (0.67) | CYP19A1MGAMRAD51MEN1KMT2A | |
| SCHEMBL2952654 | 0.82 | CYP19A1 (0.62) | CYP19A1MGAMMEN1KMT2AMAPT | |
| SCHEMBL2948668 | 0.81 | CYP19A1 (0.81) | CYP19A1RAD51MEN1KMT2A | |
| SCHEMBL2949796 | 0.81 | CYP19A1 (0.68) | CYP19A1MGAMRAD51MEN1KMT2A | |
| SCHEMBL2953659 | 0.81 | CYP19A1 (0.75) | CYP19A1MGAMRAD51MEN1KMT2A | |
| SCHEMBL2951061 | 0.80 | MGAM (0.70) | CYP19A1MGAMRAD51MEN1KMT2A | |
| SCHEMBL2942091 | 0.80 | MGAM (0.77) | CYP19A1MGAMMEN1KMT2A | |
| SCHEMBL2943609 | 0.79 | CYP19A1 (0.65) | CYP19A1MGAMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7754755-B2 | e.g. N-[2-(1H-Indol-3-yl)-ethyl]-2-methyl-5-fluoro-benzenesulfonamide; N-[3-(4-Butyl-phenoxy)-propyl]-4-pentyl-benzenesulfonamide; useful for treating inflammatory disorder, atherosclerosis, diabetes, vascular restenosis, hypertension, asthma, rheumatoid arthritis, osteoarthritis, cancer | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-07-13 | — | — | US | claimed |
| US-7754755-B2 | e.g. N-[2-(1H-Indol-3-yl)-ethyl]-2-methyl-5-fluoro-benzenesulfonamide; N-[3-(4-Butyl-phenoxy)-propyl]-4-pentyl-benzenesulfonamide; useful for treating inflammatory disorder, atherosclerosis, diabetes, vascular restenosis, hypertension, asthma, rheumatoid arthritis, osteoarthritis, cancer | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-07-13 | — | — | US | disclosed |
| US-7754755-B2 | e.g. N-[2-(1H-Indol-3-yl)-ethyl]-2-methyl-5-fluoro-benzenesulfonamide; N-[3-(4-Butyl-phenoxy)-propyl]-4-pentyl-benzenesulfonamide; useful for treating inflammatory disorder, atherosclerosis, diabetes, vascular restenosis, hypertension, asthma, rheumatoid arthritis, osteoarthritis, cancer | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-07-13 | — | — | US | disclosed |