Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | GCG | P01275 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 3/20 | 0.33 |
| ▸ | CCNC | P24863 | 2/20 | 0.33 |
| ▸ | CDK8 | P49336 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 3/20 | 0.32 |
| ▸ | MELK | Q14680 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.31 |
| ▸ | KDM4A | O75164 | 1/20 | 0.31 |
| ▸ | KDM4B | O94953 | 1/20 | 0.31 |
| ▸ | KDM5C | P41229 | 1/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | STAT3 | P40763 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | TAF1 | P21675 | 1/20 | 0.30 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.30 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22736024 | 0.86 | GRM4 (0.36) | GRM4GCGJAK1CCNCCDK8 | |
| SCHEMBL29480608 | 0.85 | GCG (0.36) | GRM4GCGJAK1JAK2KDM4A | |
| SCHEMBL29480539 | 0.85 | GCG (0.34) | GRM4GCGJAK1JAK2GCGR | |
| SCHEMBL29567903 | 0.82 | MAPK1 (0.34) | GRM4MAPK1MELKKDM4AKDM4B | |
| SCHEMBL22736180 | 0.82 | MAPK1 (0.34) | GRM4MAPK1MELKKDM4AKDM4B | |
| SCHEMBL22736009 | 0.82 | MAPK1 (0.38) | GRM4CCNCCDK8MAPK1MELK | |
| SCHEMBL29567579 | 0.82 | MAPK1 (0.38) | GRM4CCNCCDK8MAPK1MELK | |
| SCHEMBL22736186 | 0.80 | MAPK1 (0.42) | GRM4CCNCCDK8MAPK1MELK | |
| SCHEMBL29567713 | 0.80 | MAPK1 (0.42) | GRM4CCNCCDK8MAPK1MELK | |
| SCHEMBL29480476 | 0.80 | GCG (0.35) | GCGJAK1JAK2GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174294-A | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2022-03-11 | — | — | CN | claimed |
| CN-114174294-A | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2022-03-11 | — | — | CN | disclosed |