⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22736320 | 0.88 | GRM4 (0.32) | — | |
| SCHEMBL29567465 | 0.88 | GRM4 (0.32) | — | |
| SCHEMBL22736319 | 0.88 | — | — | |
| SCHEMBL22735968 | 0.85 | — | — | |
| SCHEMBL29480751 | 0.85 | — | — | |
| SCHEMBL29480652 | 0.83 | EGLN1 (0.34) | — | |
| SCHEMBL22735954 | 0.83 | EGLN1 (0.34) | — | |
| SCHEMBL29480704 | 0.83 | — | — | |
| SCHEMBL22716782 | 0.79 | JAK2 (0.36) | — | |
| SCHEMBL29480498 | 0.79 | JAK2 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174294-B | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2024-10-25 | — | — | CN | disclosed |
| EP-3976612-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD (IN) | 2022-04-06 | — | — | EP | disclosed |
| CN-114174294-A | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2022-03-11 | — | — | CN | disclosed |