Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.33 |
| ▸ | MELK | Q14680 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29480652 | 1.00 | EGLN1 (0.34) | EGLN1GRM4MELK | |
| SCHEMBL29567290 | 0.86 | EGLN1 (0.38) | EGLN1GRM4MELK | |
| SCHEMBL29480668 | 0.86 | EGLN1 (0.38) | EGLN1GRM4 | |
| SCHEMBL22736533 | 0.86 | EGLN1 (0.38) | EGLN1GRM4 | |
| SCHEMBL22735769 | 0.85 | EGLN1 (0.33) | EGLN1GRM4 | |
| SCHEMBL29480751 | 0.83 | — | — | |
| SCHEMBL22735968 | 0.83 | — | — | |
| SCHEMBL29480651 | 0.83 | — | — | |
| SCHEMBL29480690 | 0.83 | OGA (0.34) | EGLN1GRM4 | |
| SCHEMBL22735928 | 0.81 | GRM4 (0.33) | EGLN1GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |