Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.40 |
| ▸ | MTOR | P42345 | 3/20 | 0.40 |
| ▸ | CTSD | P07339 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 2/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17203201 | 0.74 | PIK3CD (0.46) | LRRK2PIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL22736088 | 0.73 | AURKA (0.52) | LRRK2MTORALOX5APFEN1CCNC | |
| SCHEMBL31182236 | 0.73 | METAP2 (0.50) | PIK3CDPIK3CBPIK3CGMTORCTSD | |
| SCHEMBL22735762 | 0.73 | JAK1 (0.41) | PIK3CDPIM1IRAK4MET | |
| SCHEMBL18985800 | 0.70 | MEN1 (0.42) | LRRK2PIK3CDPIK3CBPIK3CGALOX5AP | |
| SCHEMBL28734614 | 0.69 | LRRK2 (0.41) | LRRK2PIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL611806 | 0.68 | MAPT (0.47) | LRRK2PIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL20905869 | 0.68 | LRRK2 (0.43) | LRRK2PIM1PIM3PIM2MET | |
| SCHEMBL30961412 | 0.68 | FFAR1 (0.41) | LRRK2PIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL30961453 | 0.68 | IRAK4 (0.41) | LRRK2PIK3CDPIK3CBPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174294-A | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2022-03-11 | — | — | CN | disclosed |