Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 7/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.38 |
| ▸ | ATR | Q13535 | 2/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | USP7 | Q93009 | 1/20 | 0.32 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.31 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22736270 | 1.00 | EGLN1 (0.39) | EGLN1GRM4ATRGRM5MAP4K1 | |
| SCHEMBL29480720 | 0.84 | EGLN1 (0.37) | EGLN1GRM4ATRGRM5MAP4K1 | |
| SCHEMBL22736126 | 0.84 | EGLN1 (0.37) | EGLN1GRM4ATRGRM5MAP4K1 | |
| SCHEMBL29480740 | 0.81 | TLR7 (0.34) | EGLN1GRM4GRM5 | |
| SCHEMBL22735993 | 0.78 | EGLN1 (0.37) | EGLN1GRM4ATRGRM5 | |
| SCHEMBL29480471 | 0.78 | EGLN1 (0.37) | EGLN1GRM4ATRGRM5 | |
| Hydrochloric Acid SCHEMBL29480556 | 0.78 | EGLN1 (0.36) | EGLN1GRM4ATRGRM5 | |
| SCHEMBL22735779 | 0.75 | GRM4 (0.34) | GRM4 | |
| SCHEMBL29480658 | 0.75 | GRM4 (0.34) | GRM4 | |
| SCHEMBL22735775 | 0.75 | FEN1 (0.31) | GRM4HTR2BMTNR1AKCNH2FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174294-B | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2024-10-25 | — | — | CN | disclosed |
| EP-3976612-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD (IN) | 2022-04-06 | — | — | EP | disclosed |
| CN-114174294-A | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2022-03-11 | — | — | CN | disclosed |