Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 8/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | GCK | P35557 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.30 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.30 |
| ▸ | MET | P08581 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22736355 | 1.00 | MELK (0.33) | MELKGRM4HDAC4KDM4EABL1 | |
| SCHEMBL29480654 | 0.93 | GRM4 (0.35) | GRM4HDAC4KDM4EABL1LMNA | |
| SCHEMBL29480769 | 0.90 | MAP3K7 (0.37) | GRM4HDAC4ACVR1MET | |
| SCHEMBL22735955 | 0.90 | MAP3K7 (0.37) | GRM4HDAC4ACVR1MET | |
| SCHEMBL22736147 | 0.89 | CYP3A4 (0.31) | HDAC4CYP3A4CYP2D6GCK | |
| SCHEMBL29480757 | 0.89 | CYP3A4 (0.31) | HDAC4CYP3A4CYP2D6GCK | |
| SCHEMBL22735904 | 0.84 | KDM4A (0.36) | MELKGRM4HDAC4PDGFRAFLT3 | |
| SCHEMBL29480485 | 0.84 | KDM4A (0.36) | MELKGRM4HDAC4PDGFRAFLT3 | |
| SCHEMBL22735757 | 0.81 | HDAC4 (0.33) | GRM4HDAC4KDM4EABL1LMNA | |
| SCHEMBL29480733 | 0.81 | HDAC4 (0.33) | GRM4HDAC4KDM4EABL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976612-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD (IN) | 2022-04-06 | — | — | EP | disclosed |
| CN-114174294-A | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2022-03-11 | — | — | CN | disclosed |