Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 15/20 | 0.37 |
| ▸ | TAB1 | Q15750 | 15/20 | 0.37 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29480769 | 1.00 | MAP3K7 (0.37) | MAP3K7TAB1MAP3K12HDAC4GRM4 | |
| SCHEMBL29480761 | 0.90 | MAP3K7 (0.37) | MAP3K7TAB1MAP3K12GRM4 | |
| SCHEMBL22736348 | 0.90 | MAP3K7 (0.37) | MAP3K7TAB1MAP3K12GRM4 | |
| SCHEMBL22736355 | 0.90 | MELK (0.33) | HDAC4GRM4ACVR1MET | |
| SCHEMBL29480755 | 0.90 | MELK (0.33) | HDAC4GRM4ACVR1MET | |
| SCHEMBL29480654 | 0.90 | GRM4 (0.35) | HDAC4GRM4 | |
| SCHEMBL22735730 | 0.85 | MAP3K12 (0.34) | MAP3K7TAB1MAP3K12HDAC4GRM4 | |
| SCHEMBL29480650 | 0.85 | MAP3K12 (0.34) | MAP3K7TAB1MAP3K12HDAC4GRM4 | |
| SCHEMBL22735756 | 0.81 | CCNT1 (0.35) | — | |
| SCHEMBL29568176 | 0.81 | CCNT1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |