Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.41 |
| ▸ | TACR1 | P25103 | 3/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | GUSB | P08236 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29482052 | 1.00 | KDM1A (0.44) | KDM1AMAOBHCRTR2TACR1TAS1R3 | |
| SCHEMBL21294857 | 1.00 | KDM1A (0.44) | KDM1AMAOBHCRTR2TACR1TAS1R3 | |
| SCHEMBL29481964 | 0.88 | MAOB (0.42) | KDM1AMAOBHCRTR2TACR1TAS1R3 | |
| SCHEMBL21306627 | 0.88 | SCN9A (0.46) | KDM1AMAOBHCRTR2TACR1TAS1R3 | |
| SCHEMBL29481962 | 0.88 | MAOB (0.42) | KDM1AMAOBHCRTR2TACR1TAS1R3 | |
| SCHEMBL20063742 | 0.88 | MAOB (0.42) | KDM1AMAOBHCRTR2TACR1TAS1R3 | |
| SCHEMBL21294962 | 0.88 | MAOB (0.42) | KDM1AMAOBHCRTR2TACR1TAS1R3 | |
| SCHEMBL21307056 | 0.88 | SCN9A (0.46) | KDM1AMAOBHCRTR2TACR1TAS1R3 | |
| SCHEMBL21306626 | 0.88 | MAOB (0.42) | KDM1AMAOBHCRTR2TACR1TAS1R3 | |
| SCHEMBL20063765 | 0.86 | SCN9A (0.48) | KDM1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220081423-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2022-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220081423-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | TRPV1, HCN4, TRPA1 | KDM1A 3431/4885MAOB 1125/4885HCRTR2 1115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.