Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.42 |
| ▸ | GLS | O94925 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | YAP1 | P46937 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2946967 | 0.87 | SMN1; SMN2 (0.51) | SMN1; SMN2KDM4EPKMNR3C1ALDH1A1 | |
| SCHEMBL2948474 | 0.85 | SMN1; SMN2 (0.55) | SMN1; SMN2DEGS1KDM4EALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL2943011 | 0.84 | SMN1; SMN2 (0.54) | SMN1; SMN2DEGS1KDM4EALDH1A1GAA | |
| SCHEMBL2939976 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2DEGS1KDM4EALDH1A1GAA | |
| SCHEMBL3016029 | 0.81 | SMN1; SMN2 (0.49) | SMN1; SMN2DEGS1KDM4EALDH1A1GAA | |
| SCHEMBL13665025 | 0.79 | SMN1; SMN2 (0.50) | SMN1; SMN2KDM4EALDH1A1GAANPC1 | |
| SCHEMBL13665006 | 0.79 | SMN1; SMN2 (0.50) | SMN1; SMN2KDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL2949510 | 0.78 | SMN1; SMN2 (0.58) | SMN1; SMN2KDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL13665008 | 0.78 | SMN1; SMN2 (0.52) | SMN1; SMN2KDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL2947445 | 0.78 | SMN1; SMN2 (0.53) | SMN1; SMN2KDM4EALDH1A1GAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1489078-B1 | BENZOFURAN DERIVATIVE | MITSUBISHI TANABE PHARMA CORP (JP) | 2010-01-06 | — | — | EP | disclosed |
| US-20090209511-A1 | Benzofuran Derivatives | KAWAGUCHI TAKAYUKI | 2009-08-20 | — | — | US | disclosed |
| US-7531537-B2 | Benzofuran derivative | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2009-05-12 | — | — | US | disclosed |
| US-20050282808-A1 | Benzofuran derivative | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2005-12-22 | — | — | US | disclosed |
| EP-1489078-A1 | BENZOFURAN DERIVATIVE | Tanabe Seiyaku Co., Ltd. (JP) | 2004-12-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282808-A1 | Benzofuran derivative | F12, F2, F11 | SMN1; SMN2 3151/4885DEGS1 3464/4885KDM4E 1427/4885 |
| US-20090209511-A1 | Benzofuran Derivatives | F12, F2, F3 | SMN1; SMN2 3067/4885DEGS1 3516/4885KDM4E 1464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.