Dabelotine

Dabelotine

SCHEMBL29486227

CN1CCCc2cccc(OCC3CNCCO3)c21

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 4/20 0.56
SLC6A4 P31645 4/20 0.56
HTR2B P41595 3/20 0.56
SLC6A2 P23975 2/20 0.56
SLC6A3 Q01959 2/20 0.56
ADRB2 P07550 1/20 0.56
HTR1A P08908 1/20 0.56
ADRA1A P35348 1/20 0.56
ADRA2C P18825 1/20 0.56
HRH1 P35367 1/20 0.50
OPRD1 P41143 1/20 0.50
OPRK1 P41145 1/20 0.50
HTR3A P46098 1/20 0.50
HTR1D P28221 2/20 0.46
HTR1B P28222 2/20 0.46
CYP1A2 P05177 1/20 0.46
CYP3A4 P08684 1/20 0.46
PIM1 P11309 1/20 0.42
PIM2 Q9P1W9 1/20 0.42
HTR2C P28335 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dabelotine SCHEMBL194514 1.00 HTR2A (0.56) HTR2ASLC6A4HTR2BSLC6A2SLC6A3
Dabelotine SCHEMBL10634512 1.00 HTR2A (0.56) HTR2ASLC6A4HTR2BSLC6A2SLC6A3
Dabelotine SCHEMBL29711466 0.93 HTR1D (0.52) HTR2ASLC6A4HTR2BSLC6A2SLC6A3
Dabelotine SCHEMBL30446029 0.93 HTR1D (0.52) HTR2ASLC6A4HTR2BSLC6A2SLC6A3
SCHEMBL9528632 0.85 HTR2A (0.51) HTR2ASLC6A4HTR2BSLC6A2SLC6A3
SCHEMBL9528638 0.85 HTR2A (0.51) HTR2ASLC6A4HTR2BSLC6A2SLC6A3
SCHEMBL9368329 0.84 SLC6A4 (0.51) HTR2ASLC6A4HTR2BSLC6A2SLC6A3
SCHEMBL9368334 0.84 SLC6A4 (0.51) HTR2ASLC6A4HTR2BSLC6A2SLC6A3
SCHEMBL10634604 0.82 HRH3 (0.44) KDRHRH3
SCHEMBL10634609 0.82 HRH3 (0.44) KDRHRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115137880-B Medical equipment with coating 业聚医疗私人有限公司 2024-05-03 CN disclosed
CN-114423475-B Drug delivery device and method for delivering a drug 美国安进公司 2024-03-26 CN disclosed
CN-114521145-B Drug delivery device 美国安进公司 2024-03-26 CN disclosed
CN-117255851-A Method for perfusion culture of mammalian cells 建新公司 2023-12-19 CN disclosed
CN-115380049-A Treatment of physiological iron overload 凯玛布有限公司 2022-11-22 CN disclosed
CN-115243748-A Drug delivery member insertion sensing assembly, drug delivery device, and related methods 美国安进公司 2022-10-25 CN disclosed
CN-115209931-A Controlled dispensing syringe 美国安进公司 2022-10-18 CN disclosed
CN-114901330-A Needle shield remover, drug delivery device, and related methods 美国安进公司 2022-08-12 CN disclosed
CN-114521145-A Drug delivery device 美国安进公司 2022-05-20 CN disclosed
CN-114423475-A Drug delivery device and method for delivering a drug 美国安进公司 2022-04-29 CN disclosed