Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.51 |
| ▸ | HTR2B | P41595 | 2/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 2/20 | 0.44 |
| ▸ | HTR1B | P28222 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9528638 | 1.00 | HTR2A (0.51) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| Dabelotine SCHEMBL10634512 | 0.85 | HTR2A (0.56) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| Dabelotine SCHEMBL29486227 | 0.85 | HTR2A (0.56) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| Dabelotine SCHEMBL194514 | 0.85 | HTR2A (0.56) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL10628343 | 0.83 | PDK1 (0.45) | NOTUMALDH1A1 | |
| SCHEMBL10628341 | 0.83 | PDK1 (0.45) | NOTUMALDH1A1 | |
| Dabelotine SCHEMBL29711466 | 0.83 | HTR1D (0.52) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| Dabelotine SCHEMBL30446029 | 0.83 | HTR1D (0.52) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL9529387 | 0.81 | HRH3 (0.56) | NOTUMALDH1A1 | |
| SCHEMBL9528227 | 0.81 | HRH3 (0.56) | NOTUMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0286495-B1 | MORPHOLINE DERIVATIVES, THEIR PROCESS OF PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR ET COMPAGNIE (FR) | 1993-05-12 | — | — | EP | claimed |
| US-4782054-A | ANTIISCHEMIC, ANTIHYPOXIC, STIMULANTS | ADIR ET COMPAGNIE (FR) | 1988-11-01 | — | — | US | claimed |
| US-4782054-A | ANTIISCHEMIC, ANTIHYPOXIC, STIMULANTS | ADIR ET COMPAGNIE (FR) | 1988-11-01 | — | — | US | disclosed |