Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 17/20 | 1.00 |
| ▸ | FYN | P06241 | 3/20 | 0.77 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.68 |
| ▸ | GAK | O14976 | 1/20 | 0.68 |
| ▸ | STK10 | O94804 | 1/20 | 0.68 |
| ▸ | YES1 | P07947 | 1/20 | 0.68 |
| ▸ | RET | P07949 | 1/20 | 0.68 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.68 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.68 |
| ▸ | FLT3 | P36888 | 1/20 | 0.68 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.68 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.68 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.68 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.68 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.68 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.68 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.68 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.68 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.68 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2942420 | 0.90 | PIM1 (0.82) | PIM1FYNKCNH2GAKSTK10 | |
| SCHEMBL102851 | 0.89 | PIM1 (1.00) | PIM1KCNH2GAKSTK10YES1 | |
| SCHEMBL2945933 | 0.89 | PIM1 (0.80) | PIM1FYNKCNH2GAKSTK10 | |
| SCHEMBL13234624 | 0.87 | FYN (1.00) | PIM1FYNHASPIN | |
| SCHEMBL102542 | 0.87 | PIM1 (1.00) | PIM1KCNH2GAKSTK10YES1 | |
| SCHEMBL23299250 | 0.87 | PIM1 (0.81) | PIM1KCNH2GAKSTK10YES1 | |
| SCHEMBL19987042 | 0.86 | PIM1 (0.76) | PIM1FYNKCNH2GAKSTK10 | |
| SCHEMBL13234334 | 0.86 | PIM1 (0.75) | PIM1FYNKCNH2GAKSTK10 | |
| SCHEMBL103225 | 0.85 | PIM1 (0.85) | PIM1KCNH2GAKSTK10YES1 | |
| SCHEMBL13234318 | 0.85 | PIM1 (0.74) | PIM1FYNKCNH2GAKSTK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7750000-B2 | Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments | BAYER SCHERING PHARMA AG (DE) | 2010-07-06 | — | — | US | disclosed |
| US-7750000-B2 | Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments | BAYER SCHERING PHARMA AG (DE) | 2010-07-06 | — | — | US | disclosed |
| US-20070093490-A1 | Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2007-04-26 | — | — | US | disclosed |
| US-20070093490-A1 | Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2007-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093490-A1 | Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments | MAP4K2, MAP3K1, MAP3K2 | PIM1 365/4885FYN 421/4885KCNH2 1604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.