Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 17/20 | 0.76 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.68 |
| ▸ | GAK | O14976 | 1/20 | 0.66 |
| ▸ | STK10 | O94804 | 1/20 | 0.66 |
| ▸ | YES1 | P07947 | 1/20 | 0.66 |
| ▸ | RET | P07949 | 1/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.66 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.66 |
| ▸ | FLT3 | P36888 | 1/20 | 0.66 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.66 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.66 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.66 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.66 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.66 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.66 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.66 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.66 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.66 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2948807 | 0.86 | PIM1 (1.00) | PIM1KCNH2GAKSTK10YES1 | |
| SCHEMBL16009532 | 0.86 | FYN (0.73) | PIM1DYRK1AFYNMKNK1 | |
| SCHEMBL102542 | 0.85 | PIM1 (1.00) | PIM1KCNH2GAKSTK10YES1 | |
| SCHEMBL15699138 | 0.84 | DYRK1A (0.76) | PIM1DYRK1AFYN | |
| SCHEMBL2942420 | 0.84 | PIM1 (0.82) | PIM1KCNH2GAKSTK10YES1 | |
| SCHEMBL102851 | 0.84 | PIM1 (1.00) | PIM1KCNH2GAKSTK10YES1 | |
| SCHEMBL102421 | 0.83 | DYRK1A (0.91) | PIM1DYRK1AFYN | |
| SCHEMBL2945933 | 0.83 | PIM1 (0.80) | PIM1KCNH2GAKSTK10YES1 | |
| SCHEMBL2951228 | 0.83 | FYN (0.69) | PIM1DYRK1AKCNH2GAKSTK10 | |
| SCHEMBL102236 | 0.83 | FYN (0.79) | PIM1DYRK1AFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2734205-B1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | TOLERO PHARMACEUTICALS INC (US) | 2018-03-21 | — | — | EP | disclosed |