Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 4/20 | 0.42 |
| ▸ | UBE2N | P61088 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.37 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22862448 | 1.00 | SMN1; SMN2 (0.42) | SMN1; SMN2HTTUBE2NL3MBTL1GLA | |
| SCHEMBL29490228 | 0.84 | PDE2A (0.41) | SMN1; SMN2HTTUBE2NL3MBTL1GLA | |
| SCHEMBL22862649 | 0.84 | PDE2A (0.41) | SMN1; SMN2HTTUBE2NL3MBTL1GLA | |
| SCHEMBL29490334 | 0.82 | SMN1; SMN2 (0.45) | SMN1; SMN2HTTUBE2NL3MBTL1GLA | |
| SCHEMBL22862876 | 0.80 | SMN1; SMN2 (0.38) | SMN1; SMN2HTTUBE2NL3MBTL1GLA | |
| SCHEMBL22862657 | 0.79 | CSF1R (0.47) | SMN1; SMN2HTTUBE2NL3MBTL1PDE2A | |
| SCHEMBL38653371 | 0.79 | CSF1R (0.47) | SMN1; SMN2HTTUBE2NL3MBTL1PDE2A | |
| SCHEMBL22862442 | 0.78 | NTRK1 (0.41) | SMN1; SMN2HTTUBE2NL3MBTL1PDE2A | |
| SCHEMBL29490261 | 0.78 | NTRK1 (0.41) | SMN1; SMN2HTTUBE2NL3MBTL1PDE2A | |
| SCHEMBL22862584 | 0.76 | THRB (0.40) | SMN1; SMN2HTTUBE2NL3MBTL1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976009-A2 | BAX INHIBITORS AND USES THEREOF | Case Western Reserve University (US) | 2022-04-06 | — | — | EP | disclosed |