Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14553997 | 0.84 | SIGMAR1 (0.40) | SIGMAR1KCNH2 | |
| SCHEMBL20244826 | 0.83 | SIGMAR1 (0.42) | GAASIGMAR1ALOX15KCNH2 | |
| SCHEMBL15448530 | 0.81 | HDAC1 (0.33) | SIGMAR1 | |
| SCHEMBL25147187 | 0.80 | SIGMAR1 (0.40) | SIGMAR1LRRK2HTR3AKCNH2 | |
| SCHEMBL13179148 | 0.80 | MEN1 (0.33) | — | |
| SCHEMBL24915047 | 0.78 | GAA (0.33) | GAASMN1; SMN2 | |
| SCHEMBL17001832 | 0.77 | GAA (0.41) | GAASMN1; SMN2TLR8SIGMAR1ALOX15 | |
| SCHEMBL5800638 | 0.76 | GAA (0.40) | GAASMN1; SMN2TLR8SIGMAR1ALOX15 | |
| SCHEMBL24958715 | 0.76 | SIGMAR1 (0.31) | SIGMAR1 | |
| SCHEMBL21847657 | 0.76 | GAA (0.47) | GAASMN1; SMN2TLR8SIGMAR1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3966206-A1 | HETEROARYLAMINOPYRIMIDINE AMIDE AUTOPHAGY INHIBITORS AND METHODS OF USE THEREOF | Deciphera Pharmaceuticals, LLC (US) | 2022-03-16 | — | — | EP | disclosed |