Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL22608563 | 1.00 | HCAR2 (0.37) | HCAR2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL22816435 | 0.93 | HCAR2 (0.39) | HCAR2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL22608564 | 0.83 | PIK3CD (0.32) | HCAR2PIK3CDPIK3CAPIK3CBPIK3CG | |
| Trifluoroacetic Acid SCHEMBL22608164 | 0.79 | HAO1 (0.39) | HAO1 | |
| Trifluoroacetic Acid SCHEMBL29490726 | 0.79 | HAO1 (0.39) | HAO1 | |
| Trifluoroacetic Acid SCHEMBL29514846 | 0.71 | GRIN2D (0.42) | KDM4EALDH1A1LMNAMAPTHPGD | |
| Trifluoroacetic Acid SCHEMBL22608799 | 0.71 | GRIN2D (0.42) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL29514738 | 0.70 | HAO1 (0.43) | HAO1 | |
| SCHEMBL22816396 | 0.70 | HAO1 (0.43) | HAO1 | |
| Trifluoroacetic Acid SCHEMBL22608506 | 0.67 | NISCH (0.37) | KDM4EALDH1A1KDM1AHAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3986863-A1 | GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE | BioMarin Pharmaceutical Inc. (US) | 2022-04-27 | — | — | EP | disclosed |
| CN-114258390-A | Glycolate oxidase inhibitors for disease treatment | 生物马林药物股份有限公司 | 2022-03-29 | — | — | CN | disclosed |