Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.59 |
| ▸ | MTOR | P42345 | 11/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.59 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.59 |
| ▸ | PRKDC | P78527 | 5/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.52 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.52 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
| ▸ | MET | P08581 | 1/20 | 0.52 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.52 |
| ▸ | LTK | P29376 | 1/20 | 0.52 |
| ▸ | CDK7 | P50613 | 1/20 | 0.52 |
| ▸ | NEK2 | P51955 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.52 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.52 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24270515 | 1.00 | PIK3CA (0.59) | PIK3CAMTORPIK3CDPIK3CGPRKDC | |
| SCHEMBL29492843 | 0.80 | PIK3CA (0.78) | PIK3CAMTORPIK3CDPIK3CGPRKDC | |
| SCHEMBL24270530 | 0.80 | PIK3CA (0.78) | PIK3CAMTORPIK3CDPIK3CGPRKDC | |
| SCHEMBL24270518 | 0.79 | PIK3CA (0.47) | PIK3CAMTORPIK3CDPIK3CGPRKDC | |
| SCHEMBL29492711 | 0.79 | PIK3CA (0.47) | PIK3CAMTORPIK3CDPIK3CGPRKDC | |
| SCHEMBL24270832 | 0.79 | PRKDC (0.51) | PIK3CAMTORPIK3CDPIK3CGPRKDC | |
| SCHEMBL30578505 | 0.79 | PRKDC (0.51) | PIK3CAMTORPIK3CDPIK3CGPRKDC | |
| SCHEMBL15747768 | 0.78 | PIK3CA (0.70) | PIK3CAMTORPIK3CDPIK3CGPRKDC | |
| SCHEMBL31439311 | 0.78 | PIK3CA (0.70) | PIK3CAMTORPIK3CDPIK3CGPRKDC | |
| SCHEMBL24270535 | 0.77 | PIK3CA (0.62) | PIK3CAMTORPIK3CDPIK3CGPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4217357-A1 | NOVEL AMINOPYRIDINES AND THEIR USE IN TREATING CANCER | Auckland Uniservices Limited (NZ) | 2023-08-02 | — | — | EP | disclosed |
| WO-2022064430-A1 | NOVEL AMINOPYRIDINES AND THEIR USE IN TREATING CANCER | AUCKLAND UNISERVICES LIMITED (NZ) | 2022-03-31 | — | — | WO | disclosed |