Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.78 |
| ▸ | PRKDC | P78527 | 15/20 | 0.78 |
| ▸ | MTOR | P42345 | 12/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.44 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.43 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | NEK2 | P51955 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24270530 | 1.00 | PIK3CA (0.78) | PIK3CAPRKDCMTORPIK3CDPIK3CG | |
| SCHEMBL24270595 | 0.88 | PRKDC (1.00) | PIK3CAPRKDCMTORPIK3CDPIK3CG | |
| SCHEMBL29492845 | 0.88 | PRKDC (1.00) | PIK3CAPRKDCMTORPIK3CDPIK3CG | |
| SCHEMBL29492754 | 0.82 | PIK3CA (0.85) | PIK3CAPRKDCMTORPIK3CDPIK3CG | |
| SCHEMBL24270523 | 0.82 | PIK3CA (0.85) | PIK3CAPRKDCMTORPIK3CDPIK3CG | |
| SCHEMBL24270515 | 0.80 | PIK3CA (0.59) | PIK3CAPRKDCMTORPIK3CDPIK3CG | |
| SCHEMBL29492855 | 0.80 | PIK3CA (0.59) | PIK3CAPRKDCMTORPIK3CDPIK3CG | |
| SCHEMBL24270535 | 0.78 | PIK3CA (0.62) | PIK3CAPRKDCMTORPIK3CDPIK3CG | |
| SCHEMBL29492846 | 0.78 | PIK3CA (0.62) | PIK3CAPRKDCMTORPIK3CDPIK3CG | |
| SCHEMBL24270657 | 0.75 | PIK3CA (0.58) | PIK3CAPRKDCMTORPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116669725-A | Novel aminopyridine and use thereof in the treatment of cancer | 奥克兰联合服务有限公司 | 2023-08-29 | — | — | CN | disclosed |
| EP-4217357-A1 | NOVEL AMINOPYRIDINES AND THEIR USE IN TREATING CANCER | Auckland Uniservices Limited (NZ) | 2023-08-02 | — | — | EP | disclosed |
| WO-2022064430-A1 | NOVEL AMINOPYRIDINES AND THEIR USE IN TREATING CANCER | AUCKLAND UNISERVICES LIMITED (NZ) | 2022-03-31 | — | — | WO | disclosed |