Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.56 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.56 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3027524 | 0.84 | PDGFRB (0.41) | PRMT5WDR77AAK1DGAT1GSK3A | |
| SCHEMBL24619391 | 0.83 | PRMT5 (0.53) | PRMT5WDR77AAK1DGAT1USP30 | |
| SCHEMBL27230489 | 0.83 | PTPN1 (0.42) | PRMT5WDR77AAK1DGAT1USP30 | |
| SCHEMBL27207979 | 0.83 | PTPN1 (0.42) | PRMT5WDR77AAK1DGAT1USP30 | |
| SCHEMBL30987831 | 0.82 | AAK1 (0.41) | PRMT5WDR77AAK1DGAT1USP30 | |
| SCHEMBL18591338 | 0.82 | PRMT5 (0.53) | PRMT5WDR77AAK1DGAT1USP30 | |
| SCHEMBL1290158 | 0.80 | PRMT5 (0.57) | PRMT5WDR77AAK1DGAT1USP30 | |
| SCHEMBL17379073 | 0.80 | PRMT5 (0.50) | PRMT5WDR77AAK1DGAT1USP30 | |
| SCHEMBL3417194 | 0.79 | PRMT5 (0.49) | PRMT5WDR77AAK1DGAT1USP30 | |
| SCHEMBL30117289 | 0.79 | PRMT5 (0.56) | PRMT5WDR77AAK1DGAT1USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396301-A2 | SMALL MOLECULE BRADYKININ B1 RECEPTOR ANTAGONISTS | Jerini AG (DE) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010091876-A2 | SMALL MOLECULE BRADYKININ B1 RECEPTOR ANTAGONISTS | JERINI AG (DE) | 2010-08-19 | — | — | WO | disclosed |