Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.51 |
| ▸ | IDO1 | P14902 | 2/20 | 0.49 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PDE2A | O00408 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3490259 | 0.84 | LMNA (0.63) | LMNAMAPTCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL993223 | 0.83 | LMNA (0.58) | LMNAMAPTCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL14259451 | 0.79 | LMNA (0.58) | LMNAMAPTCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL6259515 | 0.79 | LMNA (0.58) | LMNAMAPTCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL1449607 | 0.79 | LMNA (0.58) | LMNAMAPTCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL23884845 | 0.77 | NCOA3 (0.51) | LMNAMAPTCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL27671178 | 0.77 | LMNA (0.54) | LMNAMAPTCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL25442242 | 0.76 | CYP11B1 (0.51) | LMNAMAPTCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL12586939 | 0.76 | CYP11B1 (0.57) | LMNAMAPTCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL7475855 | 0.76 | LMNA (0.53) | LMNAMAPTCYP19A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119431323-A | Heterobicyclic amides as CD38 inhibitors | 贝林格尔·英格海姆国际有限公司 | 2025-02-14 | — | — | CN | disclosed |
| CN-114423753-B | Heterobicyclic amides as CD38 inhibitors | 里邦医疗公司 | 2024-09-17 | — | — | CN | disclosed |
| EP-4003980-A1 | HETEROBICYCLIC AMIDES AS INHIBITORS OF CD38 | Ribon Therapeutics Inc. (US) | 2022-06-01 | — | — | EP | disclosed |
| CN-114423753-A | Heterobicyclic amides as CD38 inhibitors | 里邦医疗公司 | 2022-04-29 | — | — | CN | disclosed |