Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.52 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 15/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.38 |
| ▸ | EIF4E | P06730 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2951381 | 0.87 | PIK3CD (0.49) | PIK3CDPIK3R1FYNMKNK1EIF4E | |
| SCHEMBL2945059 | 0.81 | FYN (0.45) | FYNMKNK1MKNK2 | |
| SCHEMBL16023579 | 0.79 | PIK3CD (0.55) | PIK3CDPIK3R1FYNTBK1MKNK1 | |
| SCHEMBL2950866 | 0.77 | MKNK1 (0.60) | FYNMKNK1MKNK2 | |
| SCHEMBL13234229 | 0.76 | MKNK1 (0.55) | PIK3CDPIK3R1FYNMKNK1EIF4E | |
| SCHEMBL2949528 | 0.75 | PIK3CD (0.70) | PIK3CDPIK3R1FYNMKNK1 | |
| SCHEMBL2944596 | 0.75 | FYN (0.63) | FYN | |
| SCHEMBL2949820 | 0.75 | FYN (0.49) | FYN | |
| SCHEMBL2951001 | 0.74 | MKNK1 (0.47) | FYNMKNK1 | |
| SCHEMBL2945913 | 0.74 | FYN (0.49) | FYNMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7750000-B2 | Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments | BAYER SCHERING PHARMA AG (DE) | 2010-07-06 | — | — | US | disclosed |
| US-20070093490-A1 | Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2007-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093490-A1 | Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments | MAP4K2, MAP3K1, MAP3K2 | PIK3CD 101/4885PIK3R1 410/4885FYN 421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.