Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | RAMP3 | O60896 | 7/20 | 0.42 |
| ▸ | CALCR | P30988 | 7/20 | 0.42 |
| ▸ | APLNR | P35414 | 1/20 | 0.42 |
| ▸ | CALCRL | Q16602 | 3/20 | 0.41 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.41 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29496498 | 0.96 | RAMP3 (0.45) | PLK1RAMP3CALCRAPLNRCALCRL | |
| SCHEMBL29496489 | 0.96 | PLK1 (0.45) | PLK1RAMP3CALCRAPLNRITGB1 | |
| SCHEMBL29496428 | 0.95 | RAMP3 (0.43) | PLK1RAMP3CALCRAPLNRCALCRL | |
| SCHEMBL30997432 | 0.91 | RAMP3 (0.43) | PLK1RAMP3CALCRAPLNREPHA2 | |
| SCHEMBL29823809 | 0.90 | RAMP3 (0.45) | PLK1RAMP3CALCRAPLNR | |
| SCHEMBL29496452 | 0.90 | PLK1 (0.44) | PLK1RAMP3CALCRITGB1ITGA4 | |
| SCHEMBL29823805 | 0.89 | RAMP3 (0.39) | PLK1RAMP3CALCRAPLNRITGB1 | |
| SCHEMBL29496455 | 0.86 | RAMP3 (0.46) | RAMP3CALCREPHA2CTSLCTSS | |
| SCHEMBL29496425 | 0.86 | RAMP3 (0.49) | PLK1RAMP3CALCRITGB1ITGA4 | |
| SCHEMBL31307224 | 0.86 | RAMP3 (0.49) | PLK1RAMP3CALCRAPLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220235111-A1 | Variant Single-Chain Insulin Analogues | CASE WESTERN RESERVE UNIVERSITY | 2022-07-28 | — | — | US | disclosed |
| EP-3969467-A2 | VARIANT SINGLE-CHAIN INSULIN ANALOGUES | CASE WESTERN RESERVE UNIVERSITY (US) | 2022-03-23 | — | — | EP | disclosed |