Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.65 |
| ▸ | NPC1 | O15118 | 4/20 | 0.65 |
| ▸ | RAB9A | P51151 | 4/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | CASP3 | P42574 | 1/20 | 0.65 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.65 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.65 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.65 |
| ▸ | S1PR1 | P21453 | 16/20 | 0.61 |
| ▸ | S1PR3 | Q99500 | 13/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.55 |
| ▸ | RELA | Q04206 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2947283 | 0.83 | S1PR1 (0.68) | S1PR1S1PR3 | |
| SCHEMBL2939737 | 0.81 | KDM4E (0.61) | KDM4ENPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL27638547 | 0.81 | S1PR1 (0.71) | S1PR1S1PR3 | |
| SCHEMBL29362501 | 0.80 | SMN1; SMN2 (1.00) | KDM4ENPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL152658 | 0.80 | SMN1; SMN2 (1.00) | KDM4ENPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL18470571 | 0.79 | RAB9A (0.65) | KDM4ENPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL22390145 | 0.77 | NPC1 (0.74) | KDM4ENPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL13067695 | 0.77 | SMN1; SMN2 (0.85) | KDM4ENPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL17988059 | 0.76 | PTPN2 (0.53) | KDM4ENPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL3401206 | 0.76 | RAB9A (0.79) | KDM4ENPC1RAB9AHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1791592-B | Immunosuppressant compounds and compositions | IRM LLC | 2012-07-04 | — | — | CN | disclosed |
| US-7750021-B2 | Immunosuppressant compounds and compositions | IRM LLC (BM) | 2010-07-06 | — | — | US | disclosed |
| US-20090131400-A1 | IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS | IRM LLC (BM) | 2009-05-21 | — | — | US | disclosed |
| US-7417065-B2 | Immunosuppressant compounds and compositions | IRM LLC (BM) | 2008-08-26 | — | — | US | disclosed |
| CN-1791592-A | Immunosuppressant compounds and compositions | IRM LLC (BM) | 2006-06-21 | — | — | CN | disclosed |
| EP-1628967-A1 | IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS | IRM LLC (BM) | 2006-03-01 | — | — | EP | disclosed |
| US-20050014725-A1 | Immunosuppressant compounds and compositions | IRM LLC (BM) | 2005-01-20 | — | — | US | disclosed |
| WO-2005000833-A1 | IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS | IRM, LLC (BM) | 2005-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014725-A1 | Immunosuppressant compounds and compositions | ICOS, EDNRA, NFATC1 | KDM4E 2364/4885NPC1 2745/4885RAB9A 3413/4885 |
| US-20090131400-A1 | IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS | ICOS, EDNRA, NFATC1 | KDM4E 2364/4885NPC1 2745/4885RAB9A 3413/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.