Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 5/20 | 0.56 |
| ▸ | EGFR | P00533 | 4/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.54 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.54 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.48 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.48 |
| ▸ | WEE1 | P30291 | 1/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20564694 | 1.00 | FGFR1 (0.56) | FGFR1EGFRRIPK2ACVR1NOD2 | |
| SCHEMBL21990262 | 0.89 | RIPK2 (0.59) | FGFR1EGFRRIPK2ACVR1NOD2 | |
| SCHEMBL20564279 | 0.88 | RIPK2 (0.58) | FGFR1EGFRRIPK2ACVR1NOD2 | |
| SCHEMBL5764679 | 0.88 | FGFR1 (0.64) | FGFR1EGFRABL1SRCFGFR2 | |
| SCHEMBL20564693 | 0.85 | RIPK2 (0.54) | FGFR1EGFRRIPK2ACVR1NOD2 | |
| SCHEMBL29498163 | 0.85 | RIPK2 (0.54) | FGFR1EGFRRIPK2ACVR1NOD2 | |
| SCHEMBL19499678 | 0.85 | FGFR1 (0.46) | FGFR1RIPK2ACVR1NOD2FGFR2 | |
| SCHEMBL4737969 | 0.84 | LYN (0.45) | RIPK2ACVR1NOD2SRC | |
| SCHEMBL5762794 | 0.84 | FGFR1 (0.66) | FGFR1EGFRRIPK2ACVR1NOD2 | |
| SCHEMBL20563509 | 0.83 | RIPK2 (0.57) | FGFR1EGFRRIPK2ACVR1NOD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3968991-A1 | PROTEIN KINASE INHIBITORS AND USES THEREOF FOR THE TREATMENT OF DISEASES AND CONDITIONS | University of Houston System (US) | 2022-03-23 | — | — | EP | disclosed |