Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 5/20 | 0.64 |
| ▸ | EGFR | P00533 | 4/20 | 0.64 |
| ▸ | WEE1 | P30291 | 1/20 | 0.55 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.51 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29498163 | 0.88 | RIPK2 (0.54) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL20564694 | 0.88 | FGFR1 (0.56) | FGFR1EGFRWEE1SRCFGFR2 | |
| SCHEMBL20564693 | 0.88 | RIPK2 (0.54) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL29498166 | 0.88 | FGFR1 (0.56) | FGFR1EGFRWEE1SRCFGFR2 | |
| SCHEMBL5762746 | 0.86 | FGFR1 (0.48) | FGFR1EGFRWEE1SRCFGFR2 | |
| SCHEMBL20563509 | 0.86 | RIPK2 (0.57) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL29498221 | 0.86 | RIPK2 (0.57) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL5761991 | 0.85 | FGFR1 (0.70) | FGFR1EGFRWEE1SRCFGFR2 | |
| SCHEMBL30618265 | 0.85 | FGFR1 (0.70) | FGFR1EGFRWEE1SRCFGFR2 | |
| SCHEMBL5763110 | 0.84 | FGFR1 (0.72) | FGFR1EGFRWEE1SRCFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0823908-B1 | PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2006-11-02 | — | — | EP | disclosed |
| EP-0823908-A1 | PYRIDO 2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1998-02-18 | — | — | EP | disclosed |
| WO-1996034867-A1 | PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1996-11-07 | — | — | WO | disclosed |