Ethaverine

Ethaverine

SCHEMBL29500886

CCOc1ccc(Cc2nccc3cc(OCC)c(OCC)cc23)cc1OCC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE3A Q14432 10/20 1.00
SMN1; SMN2 Q16637 5/20 1.00
CYP3A4 P08684 4/20 1.00
MAPK1 P28482 4/20 1.00
LMNA P02545 3/20 1.00
CYP1A2 P05177 2/20 1.00
CYP2C9 P11712 2/20 1.00
TSHR P16473 2/20 1.00
PDE4A P27815 2/20 1.00
KCNH2 Q12809 2/20 1.00
TDP1 Q9NUW8 2/20 1.00
MEN1 O00255 1/20 1.00
ADRA2A P08913 1/20 1.00
ADORA3 P0DMS8 1/20 1.00
CHRM1 P11229 1/20 1.00
DRD1 P21728 1/20 1.00
TBXA2R P21731 1/20 1.00
ADRA1A P35348 1/20 1.00
DRD3 P35462 1/20 1.00
KMT2A Q03164 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ethaverine SCHEMBL29355739 1.00 PDE3A (1.00) PDE3ASMN1; SMN2CYP3A4MAPK1LMNA
Ethaverine SCHEMBL25606 1.00 PDE3A (1.00) PDE3ASMN1; SMN2CYP3A4MAPK1LMNA
Ethaverine SCHEMBL29624566 0.99 SMN1; SMN2 (1.00) PDE3ASMN1; SMN2CYP3A4MAPK1LMNA
Ethaverine SCHEMBL9614397 0.99 SMN1; SMN2 (1.00) PDE3ASMN1; SMN2CYP3A4MAPK1LMNA
Ethaverine SCHEMBL16180359 0.99 SMN1; SMN2 (1.00) PDE3ASMN1; SMN2CYP3A4MAPK1LMNA
Ethaverine SCHEMBL317507 0.99 SMN1; SMN2 (1.00) PDE3ASMN1; SMN2CYP3A4MAPK1LMNA
Ethaverine SCHEMBL30417501 0.99 SMN1; SMN2 (1.00) PDE3ASMN1; SMN2CYP3A4MAPK1LMNA
Ethaverine SCHEMBL17603566 0.99 PDE3A (0.97) PDE3ASMN1; SMN2CYP3A4MAPK1LMNA
SCHEMBL2455134 0.93 PDE3A (0.87) PDE3ASMN1; SMN2CYP3A4MAPK1LMNA
SCHEMBL2460329 0.91 PDE3A (0.83) PDE3ASMN1; SMN2CYP3A4MAPK1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024200612-A1 INHIBITORS OF URIDINE CATABOLISM AND/OR TRANSPORT FOR THERAPY Université de Lausanne (CH) 2024-10-03 WO claimed
EP-3663366-B1 USE OF PHYSIOLOGICAL COOLING INGREDIENTS AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS SYMRISE AG (DE) 2025-01-08 EP disclosed
WO-2024197124-A9 ARGININE VASOPRESSIN RECEPTOR (AVPR) ANTAGONISTS AND METHODS OF USING THEREOF UNIVERSITY OF MIAMI (US) 2024-12-19 WO disclosed
EP-4469439-A1 NEW COOLANTS, AND PREPARATIONS CONTAINING SAME Symrise AG (DE) 2024-12-04 EP disclosed
WO-2024200612-A1 INHIBITORS OF URIDINE CATABOLISM AND/OR TRANSPORT FOR THERAPY Université de Lausanne (CH) 2024-10-03 WO disclosed
WO-2024197124-A2 ARGININE VASOPRESSIN RECEPTOR (AVPR) ANTAGONISTS AND METHODS OF USING THEREOF UNIVERSITY OF MIAMI (US) 2024-09-26 WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 EP disclosed
CN-117597327-A Pharmaceutical preparation 第一波动生物制药股份有限公司 2024-02-23 CN disclosed
CN-116897040-A Compounds and methods for treating coronaviruses APTEEUS公司 2023-10-17 CN disclosed
EP-4247791-A2 NEW COOLANTS, AND PREPARATIONS CONTAINING SAME Symrise AG (DE) 2023-09-27 EP disclosed
EP-3675809-B1 USE OF PHYSIOLOGICAL COOLING INGREDIENTS AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS BASF SE (DE) 2023-09-27 EP disclosed
WO-2023144326-A1 NEW COOLANTS, AND PREPARATIONS CONTAINING SAME SYMRISE AG (DE) 2023-08-03 WO disclosed
WO-2023143741-A1 NEW COOLANTS, AND PREPARATIONS CONTAINING SAME SYMRISE AG (DE) 2023-08-03 WO disclosed
CN-116507327-A Chewable formulations 礼蓝动物保健有限公司 2023-07-28 CN disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed
EP-3724192-B1 TRIAZOLOBENZAZEPINES AS VASOPRESSIN V1A RECEPTOR ANTAGONISTS RICHTER GEDEON NYRT (HU) 2022-08-03 EP disclosed
CN-114795402-A Scoring balloon with translating score line 巴德股份有限公司 2022-07-29 CN disclosed
WO-2022106452-A2 NEW COOLANTS, AND PREPARATIONS CONTAINING SAME SYMRISE AG (DE) 2022-05-27 WO disclosed
WO-2022105986-A1 NOVEL COOLING AGENTS AND PREPARATIONS CONTAINING SAME SYMRISE AG (DE) 2022-05-27 WO disclosed
US-11298363-B2 Triazolobenzazepines as vasopressin V1a receptor antagonists RICHTER GEDEON NYRT. (HU) 2022-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11298363-B2 Triazolobenzazepines as vasopressin V1a receptor antagonists AVPR1B, AVPR1A, AVPR2 PDE3A 607/4885SMN1; SMN2 4312/4885CYP3A4 313/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.