SCHEMBL29501410

SCHEMBL29501410

c1ccc(Nc2cc(N3CCCC(N4CCc5ccccc5C4)CC3)ncn2)cc1

nearest known ligand 0.50

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 1/20 0.50
SMO Q99835 1/20 0.41
ADRA1A P35348 3/20 0.41
HRH4 Q9H3N8 3/20 0.40
CHRM4 P08173 1/20 0.40
PRCP P42785 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
KDR P35968 1/20 0.38
BTK Q06187 1/20 0.38
PIK3CB P42338 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26249692 1.00 SCN9A (0.50) SCN9ASMOADRA1AHRH4CHRM4
SCHEMBL26248126 0.96 SCN9A (0.53) SCN9ASMOADRA1AHRH4CHRM4
SCHEMBL26249666 0.91 SCN9A (0.50) SCN9AADRA1AHRH4CHRM4PRCP
SCHEMBL29501470 0.91 SCN9A (0.50) SCN9AADRA1AHRH4CHRM4PRCP
SCHEMBL26248321 0.89 SCN9A (0.51) SCN9ASMOADRA1AHRH4CHRM4
SCHEMBL26248494 0.89 SCN9A (0.48) SCN9ASMOADRA1AHRH4CHRM4
SCHEMBL29501484 0.89 SCN9A (0.51) SCN9ASMOADRA1AHRH4CHRM4
SCHEMBL26248568 0.89 SCN9A (0.52) SCN9ASMOADRA1AHRH4CHRM4
SCHEMBL29501356 0.88 SCN9A (0.48) SCN9ASMOADRA1AHRH4CHRM4
SCHEMBL29501346 0.88 SCN9A (0.48) SCN9ASMOADRA1AHRH4CHRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022048631-A1 COMPOUND HAVING ANTITUMOR ACTIVITY AND USE THEREOF 上海翊石医药科技有限公司 2022-03-10 WO disclosed