Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 6/20 | 0.55 |
| ▸ | VNN1 | O95497 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.48 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.47 |
| ▸ | FASN | P49327 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 2/20 | 0.45 |
| ▸ | CCNC | P24863 | 1/20 | 0.45 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.45 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19691125 | 1.00 | AR (0.55) | ARVNN1KDM4EBRD4ALDH1A1 | |
| SCHEMBL15875020 | 0.87 | AR (0.66) | ARVNN1KDM4EBRD4ALDH1A1 | |
| SCHEMBL30159522 | 0.87 | AR (0.66) | ARVNN1KDM4EBRD4ALDH1A1 | |
| SCHEMBL20239415 | 0.85 | CDK8 (0.58) | ARVNN1ALDH1A1PTGER3PDE1C | |
| SCHEMBL29794165 | 0.85 | TNKS (0.52) | VNN1PTGER3PDE1CFASNCDK8 | |
| SCHEMBL1759304 | 0.85 | TNKS (0.52) | VNN1PTGER3PDE1CFASNCDK8 | |
| SCHEMBL29819532 | 0.85 | CDK8 (0.58) | ARVNN1ALDH1A1PTGER3PDE1C | |
| SCHEMBL29069447 | 0.84 | PTGER3 (0.55) | VNN1PTGER3PDE1CFASNCDK8 | |
| SCHEMBL8296670 | 0.83 | PLAU (0.45) | ARVNN1PTGER3PDE1CFASN | |
| SCHEMBL29426218 | 0.83 | PTGER3 (0.51) | ARKDM4EBRD4ALDH1A1BRPF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4337662-A1 | C-LINKED INHIBITORS OF ENL/AF9 YEATS | Bridge Medicines (US) | 2024-03-20 | — | — | EP | disclosed |
| WO-2022240830-A1 | C-LINKED INHIBITORS OF ENL/AF9 YEATS | BRIDGE MEDICINES (US) | 2022-11-17 | — | — | WO | disclosed |
| CN-111601791-B | EZH2 inhibitors, pharmaceutically acceptable salts and polymorphs thereof, and uses thereof | 上海海雁医药科技有限公司 | 2022-10-04 | — | — | CN | disclosed |