Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2950345 | 1.00 | SMN1; SMN2 (0.41) | SMN1; SMN2FFAR1ALDH1A1GAAHPGD | |
| SCHEMBL23524596 | 0.82 | SMN1; SMN2 (0.38) | SMN1; SMN2FFAR1ALDH1A1GAAHPGD | |
| SCHEMBL6863626 | 0.81 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1GAAHPGDPPARA | |
| SCHEMBL15941562 | 0.80 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1PPARAHTTTDP1 | |
| SCHEMBL10788442 | 0.80 | TTR (0.49) | SMN1; SMN2ALDH1A1HPGDPDK1PPARA | |
| SCHEMBL7447401 | 0.78 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1PDK1PPARAXDH | |
| SCHEMBL7508888 | 0.78 | ALDH1A1 (0.51) | SMN1; SMN2ALDH1A1GAAHPGDHTT | |
| SCHEMBL8383429 | 0.77 | TTR (0.47) | SMN1; SMN2ALDH1A1GAAPDK1PPARA | |
| SCHEMBL707380 | 0.77 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1HPGDKDM4E | |
| SCHEMBL709158 | 0.77 | POLB (0.50) | SMN1; SMN2ALDH1A1GAAHPGDPDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100256130-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | GOODMAN KRISTA B | 2010-10-07 | — | — | US | disclosed |
| US-7749998-B2 | Morpholinyl and pyrrolidinyl analogs | GLAXOSMITHKLINE LLC (US) | 2010-07-06 | — | — | US | disclosed |
| US-20090275571-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | SMITHKLINE BEECHAM CORPORATION | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256130-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | UTS2R, AVPR2, VIPR2 | SMN1; SMN2 1220/4885FFAR1 2872/4885ALDH1A1 4201/4885 |
| US-20090275571-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | UTS2R, AVPR2, VIPR2 | SMN1; SMN2 1220/4885FFAR1 2872/4885ALDH1A1 4201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.