Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Gs 6201. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B known ✓ | P29275 | 20/20 | 1.00 |
| ▸ | ADORA2A | P29274 | 18/20 | 1.00 |
| ▸ | ADORA1 | P30542 | 17/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 12/20 | 1.00 |
| ▸ | PLK4 | O00444 | 1/20 | 1.00 |
| ▸ | CDK2 | P24941 | 1/20 | 1.00 |
| ▸ | IRAK1 | P51617 | 1/20 | 1.00 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 1.00 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 1.00 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gs 6201 SCHEMBL29504137 | 1.00 | ADORA2B (1.00) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| Gs 6201 SCHEMBL29504138 | 1.00 | ADORA2B (1.00) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| Gs 6201 SCHEMBL238694 | 1.00 | ADORA2B (1.00) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| Gs 6201 SCHEMBL29504135 | 1.00 | ADORA2B (1.00) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL242517 | 0.97 | ADORA2B (1.00) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL1944742 | 0.95 | ADORA2B (1.00) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL243037 | 0.93 | ADORA2B (1.00) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL243736 | 0.90 | ADORA2B (0.86) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL1944731 | 0.90 | ADORA2B (1.00) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL2685809 | 0.90 | ADORA2B (0.85) | ADORA2BADORA2AADORA1ADORA3PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4211135-A1 | COCRYSTALS OF AN ADENOSINE A2B RECEPTOR ANTAGONIST | Teon Therapeutics, Inc. (US) | 2023-07-19 | — | — | EP | claimed |
| WO-2022051589-A1 | COCRYSTALS OF AN ADENOSINE A2B RECEPTOR ANTAGONIST | TEON THERAPEUTICS, INC. (US) | 2022-03-10 | — | — | WO | claimed |
| EP-4211135-A1 | COCRYSTALS OF AN ADENOSINE A2B RECEPTOR ANTAGONIST | Teon Therapeutics, Inc. (US) | 2023-07-19 | — | — | EP | disclosed |
| WO-2022051589-A1 | COCRYSTALS OF AN ADENOSINE A2B RECEPTOR ANTAGONIST | TEON THERAPEUTICS, INC. (US) | 2022-03-10 | — | — | WO | disclosed |