SCHEMBL29504658

SCHEMBL29504658

COc1ccc2[nH]cc(C(=O)C(=O)NC3CCN(c4ccc(C)cc4Cl)C3=O)c2c1

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
B3GAT3 O94766 1/20 0.81
HTR4 Q13639 2/20 0.44
ROCK2 O75116 2/20 0.44
NPC1 O15118 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
NR4A2 P43354 1/20 0.43
GABRP O00591 1/20 0.43
GABRD O14764 1/20 0.43
GABRA1 P14867 1/20 0.43
GABRB1 P18505 1/20 0.43
GABRG2 P18507 1/20 0.43
GABRB3 P28472 1/20 0.43
GABRA5 P31644 1/20 0.43
GABRA3 P34903 1/20 0.43
GABRA2 P47869 1/20 0.43
GABRB2 P47870 1/20 0.43
GABRA4 P48169 1/20 0.43
GABRE P78334 1/20 0.43
GABRA6 Q16445 1/20 0.43
GABRG1 Q8N1C3 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28984920 0.91 B3GAT3 (0.75) B3GAT3HTR4ROCK2NR4A2GABRP
SCHEMBL30267518 0.89 B3GAT3 (1.00) B3GAT3ROCK2NR4A2TP53RAB9A
SCHEMBL28984929 0.89 B3GAT3 (1.00) B3GAT3ROCK2NR4A2TP53RAB9A
SCHEMBL28984931 0.89 B3GAT3 (0.79) B3GAT3NR4A2TP53LMNAMAPT
SCHEMBL29504713 0.89 B3GAT3 (0.79) B3GAT3NR4A2TP53LMNAMAPT
SCHEMBL29504741 0.89 B3GAT3 (0.79) B3GAT3GABRPGABRDGABRA1GABRB1
SCHEMBL29504687 0.89 B3GAT3 (0.79) B3GAT3SMN1; SMN2NR4A2
SCHEMBL28984921 0.89 B3GAT3 (0.79) B3GAT3SMN1; SMN2NR4A2
SCHEMBL28984923 0.88 B3GAT3 (0.78) B3GAT3ROCK2SMN1; SMN2KMT2AALDH1A1
SCHEMBL29504777 0.87 B3GAT3 (0.76) B3GAT3NPC1GABRPGABRDGABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114456150-A NR2B receptor antagonist or pharmaceutically acceptable salt thereof, preparation method and application 中国药科大学 2022-05-10 CN claimed
CN-114456150-A NR2B receptor antagonist or pharmaceutically acceptable salt thereof, preparation method and application 中国药科大学 2022-05-10 CN disclosed