Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.52 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.52 |
| ▸ | MPO | P05164 | 4/20 | 0.49 |
| ▸ | IDH2 | P48735 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | TNNI3K | Q59H18 | 4/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CDK7 | P50613 | 1/20 | 0.46 |
| ▸ | CCNH | P51946 | 1/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22719775 | 1.00 | MAPT (0.56) | MAPTAKR1C3AKR1C2MPOIDH2 | |
| SCHEMBL29438887 | 0.90 | AKR1C3 (0.58) | MAPTAKR1C3AKR1C2MPOIDH2 | |
| SCHEMBL22718236 | 0.90 | AKR1C3 (0.58) | MAPTAKR1C3AKR1C2MPOIDH2 | |
| SCHEMBL22719612 | 0.84 | YAP1 (0.65) | MAPTAKR1C3AKR1C2MPOIDH2 | |
| SCHEMBL29505020 | 0.84 | YAP1 (0.65) | MAPTAKR1C3AKR1C2MPOIDH2 | |
| SCHEMBL20779650 | 0.82 | MAPT (0.62) | MAPTAKR1C3AKR1C2MPOIDH2 | |
| SCHEMBL29438860 | 0.81 | MAPT (0.51) | MAPTAKR1C3AKR1C2MPOIDH2 | |
| SCHEMBL22718119 | 0.81 | MAPT (0.51) | MAPTAKR1C3AKR1C2MPOIDH2 | |
| SCHEMBL22719577 | 0.81 | MAPT (0.57) | MAPTAKR1C3AKR1C2MPOIDH2 | |
| SCHEMBL20779877 | 0.74 | MAPT (0.55) | MAPTAKR1C3AKR1C2IDH2TNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976192-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |