Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 6/20 | 0.57 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.54 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.50 |
| ▸ | TEAD4 | Q15561 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GMNN | O75496 | 1/20 | 0.50 |
| ▸ | TTR | P02766 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22719651 | 1.00 | RAPGEF4 (0.59) | RAPGEF4RXFP1P2RX1AKR1C3AKR1C2 | |
| SCHEMBL22719750 | 0.89 | MEN1 (0.60) | RAPGEF4RXFP1P2RX1AKR1C3AKR1C2 | |
| SCHEMBL22719798 | 0.87 | RAPGEF4 (0.57) | RAPGEF4RXFP1P2RX1AKR1C3AKR1C2 | |
| SCHEMBL29505150 | 0.85 | TEAD4 (0.68) | RAPGEF4RXFP1P2RX1AKR1C3AKR1C2 | |
| SCHEMBL22719664 | 0.85 | TEAD4 (0.68) | RAPGEF4RXFP1P2RX1AKR1C3AKR1C2 | |
| SCHEMBL29505051 | 0.82 | RAPGEF4 (0.51) | RAPGEF4RXFP1P2RX1AKR1C3AKR1C2 | |
| SCHEMBL22719694 | 0.82 | RAPGEF4 (0.51) | RAPGEF4RXFP1P2RX1AKR1C3AKR1C2 | |
| SCHEMBL22829737 | 0.81 | RAPGEF4 (0.53) | RAPGEF4RXFP1P2RX1AKR1C3AKR1C2 | |
| SCHEMBL12851592 | 0.81 | RXFP1 (0.78) | RXFP1AKR1C3AKR1C2LMNAALDH1A1 | |
| SCHEMBL12544169 | 0.78 | RXFP1 (0.88) | RXFP1P2RX1LMNAMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976192-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |