Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 7/20 | 0.50 |
| ▸ | AHR | P35869 | 3/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | PRKCI | P41743 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21439156 | 1.00 | RHEB (0.50) | RHEBAHRCSNK2A1CYP2A6NR4A2 | |
| SCHEMBL9333607 | 0.79 | RHEB (0.51) | RHEBAURKATPX2MTORACHE | |
| SCHEMBL31589082 | 0.79 | RHEB (0.51) | RHEBAURKATPX2MTORACHE | |
| SCHEMBL25080566 | 0.78 | RHEB (0.50) | RHEBAURKATPX2MTORBRD4 | |
| SCHEMBL31274981 | 0.77 | PARP1 (0.50) | RHEBCHEK1BRD4 | |
| SCHEMBL29644241 | 0.74 | AHR (0.54) | RHEBAHRCSNK2A1CYP2A6NR4A2 | |
| SCHEMBL1020056 | 0.74 | AHR (0.54) | RHEBAHRCSNK2A1CYP2A6NR4A2 | |
| SCHEMBL6862874 | 0.71 | RHEB (0.48) | RHEB | |
| SCHEMBL1020339 | 0.71 | RHEB (0.50) | RHEBAHRCSNK2A1CYP2A6NR4A2 | |
| SCHEMBL1431448 | 0.71 | RHEB (0.50) | RHEBAHRCSNK2A1CYP2A6NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4221756-A1 | COMPOUNDS AND THEIR USE IN TREATING CANCER | Astrazeneca AB (SE) | 2023-08-09 | — | — | EP | disclosed |
| WO-2022069520-A1 | COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2022-04-07 | — | — | WO | disclosed |