Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALKBH2 | Q6NS38 | 2/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
| ▸ | LDHB | P07195 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 15/20 | 0.44 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23012663 | 1.00 | ALKBH2 (0.46) | ALKBH2HPGDSLDHALDHBPDE10A | |
| SCHEMBL31448239 | 0.88 | PIK3CD (0.47) | ALKBH2HPGDSLDHALDHBPDE10A | |
| SCHEMBL23022181 | 0.83 | ADORA2A (0.43) | LDHALDHBPDE10APIK3CDPIK3R1 | |
| SCHEMBL23022201 | 0.80 | ADORA2A (0.46) | PIK3CDPIK3R1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL31448269 | 0.80 | ADORA2A (0.46) | PIK3CDPIK3R1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL23012226 | 0.78 | ADORA2A (0.48) | PIK3CDPIK3R1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL29507175 | 0.78 | ADORA2A (0.48) | PIK3CDPIK3R1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL31448229 | 0.76 | HDAC6 (0.41) | LDHALDHBPDE10AEGLN1PIK3CD | |
| SCHEMBL31448123 | 0.74 | ATR (0.48) | PDE10A | |
| SCHEMBL31448135 | 0.70 | PIK3CD (0.45) | ALKBH2HPGDSLDHALDHBEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119613384-A | 2-Amino substituted aza-heteroaryl compounds as HPK1 inhibitors and uses thereof | 中国药科大学 | 2025-03-14 | — | — | CN | disclosed |
| CN-114341127-B | Aminopyrazine compounds as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2024-12-17 | — | — | CN | disclosed |
| CN-114341127-A | Aminopyrazine compounds as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2022-04-12 | — | — | CN | disclosed |