Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 11/20 | 0.52 |
| ▸ | JAK1 | P23458 | 6/20 | 0.49 |
| ▸ | JAK2 | O60674 | 5/20 | 0.49 |
| ▸ | TTK | P33981 | 2/20 | 0.49 |
| ▸ | BTK | Q06187 | 2/20 | 0.45 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 3/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.40 |
| ▸ | SRC | P12931 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29508180 | 0.94 | JAK3 (0.58) | JAK3JAK1JAK2TTKBTK | |
| SCHEMBL24388579 | 0.94 | JAK3 (0.58) | JAK3JAK1JAK2TTKBTK | |
| SCHEMBL29538392 | 0.92 | JAK3 (0.50) | JAK3JAK1JAK2TTKBTK | |
| SCHEMBL29508107 | 0.91 | JAK3 (0.52) | JAK3JAK1JAK2TTKBTK | |
| SCHEMBL29508083 | 0.90 | JAK3 (0.49) | JAK3JAK1JAK2TTKBTK | |
| Pebezertinib SCHEMBL29538037 | 0.89 | JAK3 (0.49) | JAK3JAK1JAK2TTKBTK | |
| SCHEMBL24388357 | 0.87 | JAK3 (0.57) | JAK3JAK1JAK2TTKBTK | |
| SCHEMBL29507977 | 0.87 | JAK3 (0.57) | JAK3JAK1JAK2TTKBTK | |
| SCHEMBL24388530 | 0.87 | JAK3 (0.57) | JAK3JAK1JAK2TTKBTK | |
| SCHEMBL24388546 | 0.87 | JAK3 (0.61) | JAK3JAK1JAK2TTKBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4237088-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | Blueprint Medicines Corporation (US) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022094355-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | LENGO THERAPEUTICS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |