Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 11/20 | 0.50 |
| ▸ | JAK2 | O60674 | 4/20 | 0.45 |
| ▸ | JAK1 | P23458 | 4/20 | 0.45 |
| ▸ | TTK | P33981 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 2/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24392983 | 0.94 | JAK3 (0.56) | JAK3JAK2JAK1TTKBTK | |
| SCHEMBL29508083 | 0.94 | JAK3 (0.49) | JAK3JAK2JAK1TTKBTK | |
| SCHEMBL29508037 | 0.92 | JAK3 (0.52) | JAK3JAK2JAK1TTKBTK | |
| Pebezertinib SCHEMBL29538037 | 0.91 | JAK3 (0.49) | JAK3JAK2JAK1TTKBTK | |
| Trifluoroacetic Acid SCHEMBL29250678 | 0.90 | JAK3 (0.52) | JAK3JAK2JAK1TTKBTK | |
| Trifluoroacetic Acid SCHEMBL29537647 | 0.90 | JAK3 (0.52) | JAK3JAK2JAK1TTKBTK | |
| SCHEMBL29508010 | 0.88 | JAK3 (0.54) | JAK3JAK2JAK1TTKBTK | |
| SCHEMBL24388610 | 0.88 | JAK3 (0.54) | JAK3JAK2JAK1TTKBTK | |
| SCHEMBL24388543 | 0.88 | JAK3 (0.56) | JAK3JAK2JAK1TTKBTK | |
| SCHEMBL29508038 | 0.88 | JAK3 (0.56) | JAK3JAK2JAK1TTKBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4237418-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | Blueprint Medicines Corporation (US) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022094354-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | LENGO THERAPEUTICS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |