Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MPI | P34949 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 7/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.32 |
| ▸ | TYR | P14679 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25347030 | 1.00 | PRKDC (0.44) | PRKDCCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL31541661 | 0.79 | PRKDC (0.44) | PRKDCCYP3A4ALDH1A1KDM4EMAPT | |
| SCHEMBL21582002 | 0.77 | CYP1A2 (0.51) | PRKDCCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL25343459 | 0.76 | TDP1 (0.44) | CYP1A2CYP3A4ALDH1A1KMT2AMAPT | |
| SCHEMBL30519502 | 0.76 | TDP1 (0.44) | CYP1A2CYP3A4ALDH1A1KMT2AMAPT | |
| SCHEMBL20539389 | 0.75 | TDP1 (0.41) | PRKDCCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL29580781 | 0.75 | TDP1 (0.41) | PRKDCCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL20719582 | 0.74 | ALDH1A1 (0.42) | PRKDCCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL30448383 | 0.74 | ALDH1A1 (0.42) | PRKDCCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL16896834 | 0.73 | CYP1A2 (0.56) | PRKDCCYP1A2CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076973-A1 | 7-AZAINDOLE COMPOUNDS FOR INHIBITION OF BCR-ABL TYROSINE KINASES | ENLIVEN THERAPEUTICS, INC. (US) | 2022-04-14 | — | — | WO | disclosed |