Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 6/20 | 0.38 |
| ▸ | CCND1 | P24385 | 4/20 | 0.38 |
| ▸ | JAK1 | P23458 | 3/20 | 0.38 |
| ▸ | CDK4 | P11802 | 8/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650580 | 0.74 | CHRNB2 (0.52) | BRAFMAP3K12PARP1PARP2 | |
| SCHEMBL17489094 | 0.74 | CDK4 (0.63) | CDK6CCND1CDK4BRAFCDK1 | |
| SCHEMBL20153226 | 0.72 | CHRNB2 (0.56) | CHRNB4CHRNA3BRAFMAP3K12PARP1 | |
| SCHEMBL23296211 | 0.72 | CCNA2 (0.57) | CDK6CCND1CDK4CDK1 | |
| SCHEMBL30541026 | 0.70 | CDK6 (0.54) | CDK6CCND1CDK4CDK1 | |
| SCHEMBL29684118 | 0.67 | CDK6 (0.58) | CDK6CCND1CDK4CDK1 | |
| SCHEMBL23296218 | 0.67 | CDK6 (0.58) | CDK6CCND1CDK4CDK1 | |
| SCHEMBL30541143 | 0.67 | CCNA2 (0.49) | CDK6CCND1CDK4CDK1 | |
| SCHEMBL8012152 | 0.66 | DRD3 (0.40) | BRAFMAP3K12 | |
| SCHEMBL25135260 | 0.66 | CDK4 (0.59) | CDK6CCND1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4214213-A1 | CDK INHIBITORS AND THEIR USE AS PHARMACEUTICALS | Prelude Therapeutics, Incorporated (US) | 2023-07-26 | — | — | EP | claimed |
| WO-2022061273-A1 | CDK INHIBITORS AND THEIR USE AS PHARMACEUTICALS | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2022-03-24 | — | — | WO | claimed |