Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.49 |
| ▸ | ACLY | P53396 | 3/20 | 0.46 |
| ▸ | TCF4 | P15884 | 2/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.43 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.42 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | PLAU | P00749 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LOX | P28300 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24330985 | 1.00 | SLC40A1 (0.49) | SLC40A1ACLYTCF4CTNNB1HSPD1 | |
| SCHEMBL24330996 | 0.90 | SLC40A1 (0.48) | SLC40A1ACLYTCF4CTNNB1HSPD1 | |
| SCHEMBL29515366 | 0.90 | SLC40A1 (0.48) | SLC40A1ACLYTCF4CTNNB1HSPD1 | |
| SCHEMBL29515378 | 0.90 | KDM4E (0.47) | ACLYCA1CA2ALDH1A1MEN1 | |
| SCHEMBL24330983 | 0.90 | KDM4E (0.47) | ACLYCA1CA2ALDH1A1MEN1 | |
| SCHEMBL25359894 | 0.88 | SLC40A1 (0.47) | SLC40A1ACLYTCF4CTNNB1HSPD1 | |
| SCHEMBL29515546 | 0.88 | SLC40A1 (0.47) | SLC40A1ACLYTCF4CTNNB1HSPD1 | |
| SCHEMBL24331458 | 0.88 | SLC40A1 (0.47) | SLC40A1ACLYTCF4CTNNB1HSPD1 | |
| SCHEMBL29515216 | 0.88 | SLC40A1 (0.47) | SLC40A1ACLYTCF4CTNNB1HSPD1 | |
| SCHEMBL24331485 | 0.87 | SLC40A1 (0.46) | SLC40A1ACLYTCF4CTNNB1HSPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025076235-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2025-04-10 | — | — | WO | disclosed |
| EP-4225761-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| EP-4225762-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076618-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |
| WO-2022076620-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |