Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 11/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.62 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.58 |
| ▸ | PRKACA | P17612 | 1/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.52 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24359615 | 0.91 | HDAC1 (0.67) | HDAC1HDAC6HDAC9HDAC2HDAC3 | |
| SCHEMBL29516151 | 0.90 | HDAC1 (0.61) | HDAC1HDAC6HDAC9HDAC2HDAC3 | |
| SCHEMBL29516132 | 0.90 | HDAC1 (0.64) | HDAC1HDAC6HDAC9HDAC2HDAC3 | |
| SCHEMBL29516263 | 0.89 | HDAC1 (0.59) | HDAC1HDAC6HDAC9HDAC2HDAC3 | |
| SCHEMBL29516173 | 0.86 | HDAC1 (0.66) | HDAC1HDAC6HDAC9HDAC2HDAC3 | |
| SCHEMBL29515970 | 0.84 | HDAC1 (0.59) | HDAC1HDAC6HDAC9HDAC2HDAC3 | |
| SCHEMBL29516155 | 0.84 | HDAC1 (0.64) | HDAC1HDAC6HDAC9HDAC2HDAC3 | |
| SCHEMBL24359487 | 0.84 | HDAC1 (0.69) | HDAC1HDAC6HDAC9HDAC2HDAC3 | |
| SCHEMBL29516174 | 0.83 | HDAC1 (0.57) | HDAC1HDAC6HDAC9HDAC2HDAC3 | |
| SCHEMBL29516227 | 0.82 | MAPT (0.66) | HDAC1HDAC6HDAC9HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022087456-A1 | NEW COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-04-28 | — | — | WO | disclosed |